Neurotransmitter Detection

Neurotransmitters are chemicals that transmit messages between neurons or between neurons and effector cells, act as "messengers" throughout the process. According to the chemical composition characteristics of neurotransmitters, there are mainly cholines, monoamines, amino acids and neuropeptides, etc. Currently, neurotransmitters that have been identified include dopamine, norepinephrine, acetylcholine, serotonin and so on.

In the process of neuron information transmission, when a neuron is stimulated by signals from the environment or other neurons, the transmitters stored in the presynaptic vesicles can be released to the synaptic cleft and act on the postsynaptic membrane and transmitting transmitter signals to the next neuron. Neurotransmitters mainly transmit signals in paracrine mode, so they are fast and accurate. The termination of the transmitter signal can depend on the decomposition and destruction of the corresponding hydrolase on the synaptic cleft or posterior membrane, or the body weight uptake by the presynaptic membrane-specific transporter.

Application of Neurotransmitter Detection

In recent years, neurotransmitters have become the subject of intensive research. For instance, acetylcholine has been widely studied due to its effect on alertness, memory and learning, which are essential neurotransmitters in the central nervous system. In addition, the detection of neurotransmitters also plays a very important role in the study of epilepsy, Parkinson's disease, metabolic diseases and tumors.

Our Service Process

Service Offering

Creative Biogene's neurotransmitter detection service provides results including,

• Raw data
• Experimental steps
• Related mass spectrometry parameters
• Quantitative or qualitative information of the identified substance
• Mass spectrum picture
• Bioinformatics analysis report

Our bioinformatics analysis covers a wide range including transition pair selection, standard curve drawing, data quality control, quantitative results of target small molecules, comparative group analysis and phenotypic analysis, etc.

Detection Index

Acetylcholine, catecholamine, serotonin, γ-aminobutyric acid and histamine.

Detection platform

Instrument platform: LC-MS-MS and MRM.

Turnaround Time

In general, our turnaround time is 3-5 weeks depending on the size of your project.

Advantages of Our Services 

• We use the MRM method, which shows the characteristics of strong specificity and high sensitivity
• The accuracy of our results is high because of the advanced detection platforms.
• Our exclusive kit is specifically designed for bile acids and can achieve precise quantification.
• We can combine the demands of customers, and negotiate to determine the content of services.

Creative Biogene has excellent microbiology experts, well-established metabolome detection platforms, and professional bioinformatics analysis to provide you with a one-stop service in neurotransmitter detection. Our services include sample collection, metabolite extraction, pre-processing, detection and analysis.

If you are interested in our services, please contact us for more details.